Synthesis and Characterization of Related Substances of Rupatadine Fumarate: an Antihistamine Drug
نویسندگان
چکیده
Rupatadine fumarate is a potent dual antagonist of histamine and platelet-activating factor antagonist (PAF antagonist) and used to treat allergies. During the process development of rupatadine fumarate, five related substances were observed in Rupatadine fumarate and one new related compound was observed during the stress oxidative degradation study. These related substances were identified as process related impurities, starting material related impurity and oxidative degradation related impurity. Present work describes the synthesis and characterization of all these impurities.
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